Caprospinol

Caprospinol (SP-233) is a steroid compound candidate based on the structure of 22R-hydroxycholesterol. It has multiple mechanisms of neuroprotection, including binding to β-amyloid protein (Aβ (42) ), interacting with the mitochondrial respiratory chain, clearing Aβ (42) monomers, and acting as a σ-1 receptor ligand. It can cross the blood-brain barrier in vivo and restore cognitive impairment, and has the potential to inhibit Alzheimer's disease.

Product Specifications

CAS Number

[4952-56-1]

Product Name Alternative

SP-233

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Amyloid-β; Sigma Receptor

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/caprospinol.html

Smiles

C[C@@]12[C@]3([H])[C@@](C[C@@]1([H])[C@@]4([H])[C@]([C@@]5(C(C[C@H](CC5)OC(CCCCC)=O)=CC4)C)([H])CC2)([H])O[C@]6(CC[C@H](CO6)C)[C@H]3C

Molecular Formula

C33H52O4

Molecular Weight

512.76

Precautions

P261-P280-P302+P352

References & Citations

[1]Caprospinol: discovery of a steroid drug candidate to treat Alzheimer's disease based on 22R-hydroxycholesterol structure and properties|[2]Caprospinol: moving from a neuroactive steroid to a neurotropic drug