rel-Levormeloxifene
Product Specifications
UNSPSC Description
rel-Levormeloxifene (rel-L-Centchroman) is the relative configuration of Levormeloxifene (HY-122359). rel-Levormeloxifene is a selective estrogen receptor modulator (SERM). rel-Levormeloxifene inhibits proliferation of leukemia cells with IC50 about 7 μM, arrests cell cycle at G0/G1 phase, and induces apoptosis. rel-Levormeloxifene induces differentation of myelogenesis leukemia, and enhances ROS production in K562 cells[1].
Target Antigen
Apoptosis; Estrogen Receptor/ERR; Reactive Oxygen Species
Type
Reference compound
Related Pathways
Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB;Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rel-levormeloxifene.html
Smiles
CC1(C)[C@@H](C2=CC=CC=C2)[C@H](C3=CC=C(OCCN4CCCC4)C=C3)C5=CC=C(OC)C=C5O1
Molecular Weight
457.60
References & Citations
[1]Pooja PAL, et al., An anti-leukemic agent useful for inducing differentiation in myeloid leukemia cells. WO2015044950.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-122359A/rel-Levormeloxifene-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-122359A/
Clinical Information
Phase 3
CAS Number
31477-60-8
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