PenCB
PenCB (PCB 118) could induces pyroptosis by priming and activating NFκB-dependent NLRP3 inflammasome. PCB 118 induces oxidative stress and pyroptosis are dependent on Aryl hydrocarbon receptor (AhR) activation and subsequent cytochrome P450 1A1 upregulation[1].
Product Specifications
CAS Number
[31508-00-6]
Product Name Alternative
PCB 118
UNSPSC
12352005
Hazard Statement
H373, H410
Target
Pyroptosis
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pencb.html
Purity
99.94
Solubility
10 mM in DMSO
Smiles
ClC1=C(C=C(C(C2=CC=C(C(Cl)=C2)Cl)=C1)Cl)Cl
Molecular Formula
C12H5Cl5
Molecular Weight
326.44
Precautions
H373, H410
References & Citations
[1]Yang Long, et al. ROS-induced NLRP3 inflammasome priming and activation mediate PCB 118- induced pyroptosis in endothelial cells. Ecotoxicol Environ Saf. 2020 Feb:189:109937.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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