AA43279
Product Specifications
UNSPSC Description
AA43279 is an in gamma-aminobutyric acid (GABA) fast-firing interneurons located activator for Nav1.1 channel (SCN1A) with an EC50 of 9.5 μM. AA43279 enhances specific neuronal firing activity in vitro, and exhibits anticonvulsant activity in rat MEST model[1].
Target Antigen
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/aa43279.html
Purity
98.0
Smiles
O=C(C1=C(N)C=C(C2=CC=C(OC)C=C2)S1)N
Molecular Weight
248.31
References & Citations
[1]Frederiksen K, et al., A small molecule activator of Nav 1.1 channels increases fast-spiking interneuron excitability and GABAergic transmission in vitro and has anti-convulsive effects in vivo. Eur J Neurosci. 2017 Aug;46(3):1887-1896.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-125928/AA43279-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-125928/
Clinical Information
No Development Reported
CAS Number
354812-16-1
Curated Selection
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