Imipramine

Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC50 value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects[1][2][3][4][5].

Product Specifications

CAS Number

[50-49-7]

UNSPSC

12352005

Hazard Statement

H302, H336, H370, H400

Target

Apoptosis; Autophagy; Serotonin Transporter

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/imipramine.html

Purity

99.88

Solubility

DMSO : 200 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CN(C)CCCN1C2=CC=CC=C2CCC3=CC=CC=C31

Molecular Formula

C19H24N2

Molecular Weight

280.42

Precautions

H302, H336, H370, H400

References & Citations

[1]Alburquerque-González B, et al. New role of the antidepressant imipramine as a Fascin1 inhibitor in colorectal cancer cells. Exp Mol Med. 2020 Feb;52 (2) :281-292.|[2]Jeon SH, et al. The tricyclic antidepressant imipramine induces autophagic cell death in U-87MG glioma cells. Biochem Biophys Res Commun. 2011 Sep 23;413 (2) :311-7. |[3]Xia Z, et al. The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation. J Biochem Mol Toxicol. 1999;13 (6) :338-47. |[4]Ramirez K, et al. Imipramine attenuates neuroinflammatory signaling and reverses stress-induced social avoidance. Brain Behav Immun. 2015 May;46:212-20.|[5]Balkovetz DF, et al. Evidence for an imipramine-sensitive serotonin transporter in human placental brush-border membranes. J Biol Chem. 1989 Feb 5;264 (4) :2195-8.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Citation 01

Int Immunopharmacol. 2025 Jan 6:147:113969.|Nat Chem Biol. 2024 Jul;20 (7) :857-866.|Cell Commun Signal. 2023 May 25;21 (1) :123.|Inflammation. 2021 Aug;44 (4) :1381-1395.|J Agric Food Chem. 2024 Jul 24;72 (29) :16177-16190.|Pathogens. 2022 May 22;11 (5) :602.