Rintodestrant
Product Specifications
UNSPSC Description
Rintodestrant (G1T48) is an orally active, non-steroidal and selective estrogen receptor degrader. Rintodestrant (G1T48) is also a CDK4/6 inhibitor[1].
Target Antigen
CDK; Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rintodestrant.html
Smiles
O=C(C(C(C)=CC(F)=C1)=C1C)C(SC2=C3)=C(C2=CC=C3O)OC(C=C4)=CC=C4/C=C/C(O)=O
Molecular Weight
462.49
References & Citations
[1]Kaitlyn J Andreano, et al. G1T48, an oral selective estrogen receptor degrader, and the CDK4/6 inhibitor lerociclib inhibit tumor growth in animal models of endocrine-resistant breast cancer. Breast Cancer Res Treat. 2020 Apr;180(3):635-646.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-137449/Rintodestrant-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-137449/Rintodestrant-SDS-MedChemExpress.pdf
CAS Number
2088518-51-6
Available Sizes
Curated Selection
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