Rintodestrant
Rintodestrant (G1T48) is an orally active, non-steroidal and selective estrogen receptor degrader. Rintodestrant (G1T48) is also a CDK4/6 inhibitor[1].
Product Specifications
CAS Number
[2088518-51-6]
Product Name Alternative
G1T48
UNSPSC
12352005
Target
CDK; Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Vitamin D Related/Nuclear Receptor
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rintodestrant.html
Concentration
10mM
Purity
99.91
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(C(C(C)=CC(F)=C1)=C1C)C(SC2=C3)=C(C2=CC=C3O)OC(C=C4)=CC=C4/C=C/C(O)=O
Molecular Formula
C26H19FO5S
Molecular Weight
462.49
References & Citations
[1]Kaitlyn J Andreano, et al. G1T48, an oral selective estrogen receptor degrader, and the CDK4/6 inhibitor lerociclib inhibit tumor growth in animal models of endocrine-resistant breast cancer. Breast Cancer Res Treat. 2020 Apr;180 (3) :635-646.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
Curated Selection
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