Liranaftate

Liranaftate (Piritetrate) is a squalene epoxidase inhibitor with anti-fungicidal activities. Liranaftate can be used for the research of dermatophytes. Liranaftate also suppresses fungal element-promoted production of IL-8 and experimental inflammation[1][2][3][4].

Product Specifications

CAS Number

[88678-31-3]

Product Name Alternative

Piritetrate; M-732

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Fungal

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Liranaftate.html

Purity

99.68

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

S=C(OC1=CC=C2CCCCC2=C1)N(C3=NC(OC)=CC=C3)C

Molecular Formula

C18H20N2O2S

Molecular Weight

328.43

Precautions

H302, H315, H319, H335

References & Citations

[1]Oku, Y., et al., [Fungicidal activity of liranaftate against Trichophyton rubrum]. Nihon Ishinkin Gakkai Zasshi, 2002. 43 (3) : p. 181-7.|[2]Oku, Y., N. Takahashi, and K. Yokoyama, [Fungicidal activity of liranaftate against dermatophytes]. Nihon Ishinkin Gakkai Zasshi, 2009. 50 (1) : p. 9-13.|[3]Maruyama N, et, al. [Suppression of experimental inflammation by anti-fungal agent liranaftate in mice]. Nihon Ishinkin Gakkai Zasshi. 2010;51 (1) :7-11.|[4]Kobayashi M, et, al. [Anti-fungal drug liranaftate suppresses fungal element-promoted production of IL-8 in normal human keratinocytes]. Nihon Ishinkin Gakkai Zasshi. 2008;49 (4) :319-22.