ML204

ML204 is a potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca2+ channels[1][2].

Product Specifications

CAS Number

[5465-86-1]

UNSPSC

12352005

Hazard Statement

H302

Target

TRP Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ML204.html

Purity

98.45

Solubility

DMSO : ≥ 37 mg/mL|Ethanol : 50 mg/mL (ultrasonic)

Smiles

CC1=CC(N2CCCCC2)=NC3=CC=CC=C13

Molecular Formula

C15H18N2

Molecular Weight

226.32

Precautions

H302

References & Citations

[1]Miller M, et al. Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels. J Biol Chem. 2011 Sep 23;286 (38) :33436-46.|[2]Miller MR, et al. Novel Chemical Inhibitor of TRPC4 Channels. Probe Reports from the NIH Molecular Libraries Program [Internet].|[3]Thomas Schaldecker, et al. Inhibition of the TRPC5 ion channel protects the kidney filter. J Clin Invest. 2013 Dec 2; 123 (12) : 5298–5309.|[4]Domingos M S Pereira, et al. Transient Receptor Potential Canonical Channels 4 and 5 Mediate Escherichia coli-Derived Thioredoxin Effects in Lipopolysaccharide-Injected Mice. Oxid Med Cell Longev. 2018 Jun 10;2018:4904696.