AI-4-57

AI-4-57 is an allosteric inhibitor for CBFβ SMMHC-RUNX1 (core binding factor β and the smooth-muscle myosin heavy chain) interaction with an IC50 of 22 μM[1].

Product Specifications

CAS Number

[63053-14-5]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

RUNX

Type

Reference compound

Related Pathways

Stem Cell/Wnt; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ai-4-57.html

Smiles

COC1=CC=C2N=C(C3=NC=CC=C3)NC2=C1

Molecular Formula

C13H11N3O

Molecular Weight

225.25

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501

References & Citations

[1]Illendula A, et al., A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice. Science. 2015 Feb 13;347 (6223) :779-84.