Galanthamine HBr
Acetylcholinesterase inhibitor
Product Specifications
Background
Galantamine hydrobromide is a long-acting, active acetylcholinesterase inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors (1,2). It prevents β-amyloid-induced apoptosis in SH-SY5Y (3). Long-term administration in a mouse model of Alzheimer's disease reduces amyloid precursor protein deposition and neurodegeneration in these mice (4,5).
Product Name Alternative
Galantamine hydrobromide, Galantamine HBr, Galanthamine hydrobromide, Galanthamine, Galanthamine hydrogen bromide, SPECTRUM1501202, 1,2,3,4,6,7,7a,11c-Octahydro-9-methoxy-2-methyl-benzofuro(4,3,2-efg)(2)benzazocin-6-ol HBr, LS-185021, Galanthamine, Nivalin, Reminyl, Jilkon hydrobromide, Lycoremine hydrobromide
UNSPSC
41116105
Source
Synthetic
Purity
>97% (HPLC); NMR (Conforms)
Weight
0.1
Format
White powder
Solubility
Soluble in water (12 mg/ml) or in DMSO (10 mg/ml)
Molecular Formula
C17H22BrNO3
Molecular Weight
368.3
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. M Racchi et al. Pharmacol. Res. 2004 50:441
2. M Samochocki et al. J. Pharmacol. Exp. Ther. 2003 305:1024
3. E Arias et al. Neuropharmacology 2004 46:103
4. K Rockwood et al. J. Neurol. Neurosurg. Psychiatry 2001 71:589
5. S Chen et al. Curr. Neuropharmacol. 2007 5:127
CAS Number
1953-04-4
Curated Selection
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