FTY720 Hydrochloride
S1P receptor ligand
Product Specifications
Background
FTY720 is a potent sphingosine 1-phosphate receptors (S1P) agonist once it is phosphorylated by sphingosine kinase. This causes lymphocytes to be sequestered in lymph nodes, which also makes FTY720 an immune modulating drug for multiple sclerosis. It has been shown to stimulate neuronal gene expression, axonal growth and regeneration (3). And recently FTY720 has also been shown to reduce α-Synuclein pathology in parkinsonian GM2+/- Mice (4).
Product Name Alternative
2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol,hydrochloride; Fingolimod
UNSPSC
41116105
Source
Synthetic
Purity
>98% (TLC); NMR (Conforms)
Weight
0.025
Format
White solid
Solubility
Soluble to 100 mg/ml in DMSO or to 40 mg/ml in ethanol (warmed)
Molecular Formula
C19H34ClNO2
Molecular Weight
343.9
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Wolf A., et al. (2009) J Immunol. 183(6): 3751-60.
2. Brinkmann V., et al. (2002) J Biol Chem. 277(24): 21453-7. 3. Anastasiadou S., and Knoll B. (2016) Exp. Neurol. 279: 243-260. 4. Vidal-Martinez G., at al. (2019) Neuroscience. 411: 1-10.
CAS Number
162359-56-0
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