SC 79
Akt kinase activator
Product Specifications
Background
SC 79 is an activator of Akt (protein kinase B). Specifically, it has been shown to bind the plecktrin homology (PH) domain of Akt. This mimics the binding of Phosphatidylinositol (3,4,5)-trisphosphates, which induces a conformational change in Akt, that enhances phosphorylation and activation.
CAS Number
305834-79-1
Product Name Alternative
SC-79, SC79, 2-Amino-6-chloro-α-cyano-3- (ethoxycarbonyl) -4H-1-benzopyran-4-acetic acid ethyl ester
UNSPSC
41116105
Type
Activator
Source
Synthetic
Field of Research
Cell Signaling
Purity
98% (TLC) ; NMR (Conforms)
Weight
0.025
Format
White solid
Solubility
May be dissolved in DMSO (100mg/mL); or ethanol (40mg/mL, warm)
Molecular Formula
C17H17ClN2O5
Molecular Weight
364.8
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Jo H., et al. (2012) Pro. Nat. Acad. Sci. USA. 109(26): 10581–10586.
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