H89 Dihydrochloride

PKA inhibitor

Product Specifications

Background

H89 Dihydrochloride is a potent and selective inhibitor of cAMP-dependent protein kinase (PKA). It has also been shown to inhibit CaM kinase II, casein kinase I and MYLK, as well as, Rsk-2, MSK1, Akt1, PKC µ, Rock-2, p70 S6 kinase α. H89 Dihydrochloride can induce apoptosis. It is cell permeable.

Product Name Alternative

N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide . 2HCl

UNSPSC

41116105

Source

Synthetic

Purity

99% (TLC)

Weight

0.025

Format

White to off-white solid

Solubility

Soluble in DMSO (25 mg/ml), methanol and 50% ethanol/water (20 mg/ml)

Molecular Formula

C20H22BrCl2N3O2S

Molecular Weight

519.3

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Bouschet, T., (2003) J. Biol. Chem. 278(7): 4778–4785. 2. Findik D., Song Q., Hidaka H., & Lavin M. (1995) J. Cell. Biochem. 57(1): 12–21. 3. Davies S. P., Reddy H., Caivano M., & Cohen P. (2000) Biochem. J. 351(Pt 1): 95–105.