b-AP15 (NSC-687852)
DUB inhibitor
Product Specifications
Background
Abrogates the deubiquitinating activity of the 19S regulatory particle by inhibiting ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) resulting in accumulation of polyubiquitin in cells. b-AP15 induces tumor cell apoptosis and tumor progression in four different solid tumor models in vivo.
Product Name Alternative
(3E,5E)-1-Acryloyl-3,5-bis(4-nitrobenzylidene)-4-piperidinone
UNSPSC
41116105
Source
Synthetic
Purity
>98%
Weight
0.005
Format
Pale Yellow Solid
Solubility
Soluble in 35 mg/ml DMSO
Molecular Formula
C22H17N3O6
Molecular Weight
419.4
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. D'Arcy P., et al. (2011) Nature Medicine 17: 1636.
CAS Number
1009817-63-3
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