Celastrol

Proteasome inhibitor

Product Specifications

Background

Displays potent antioxidant and anti-inflammatory activity. Inhibits NFB (IC50=270 nM). It induces heat shock response and cytoprotection in various cells. It inhibits 20S proteasome chymotrypsin activity (IC50=2.5 M). Cell permeable.

CAS Number

34157-83-0

Product Name Alternative

3-hydroxy-9β, 13α-dimethyl-2-oxo-24, 25, 26-trinoroleana-1 (10), 3, 5, 7-tetraen-29-oic acid, 10-Hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-picene-2-carboxylic acid, Tripterin

UNSPSC

41116105

Type

Inhibitor

Source

Synthetic

Field of Research

Cancer | Apoptosis | Cancer Growth Inhibitors | Proteasome Inhibitors

Purity

>98%

Weight

0.05

Format

Red Powder

Solubility

Soluble in 45 mg/ml DMSO, 30 mg/ml Ethanol

Molecular Formula

C29H38O4

Molecular Weight

450.6

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Sethi G., et al. (2007) Blood109: 2727. 2. Westerheide S.D., et al. (2004) J. Biol. Chem. 279: 56053. 3. Yang H., et al. (2006) Cancer Res. 66: 4758.