Tolinapant

Tolinapant (ASTX660) is an orally bioavailable dual antagonist of cellular inhibitor of apoptosis protein (cIAP) and X-linked inhibitor of apoptosis protein (XIAP) .

Product Specifications

CAS Number

[1799328-86-1]

Product Name Alternative

ASTX660

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; IAP

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tolinapant.html

Purity

99.81

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@H]1N(C[C@@H]2N(CC(N3CC(C)(C)C4=NC(CO)=C(CC5=CC=C(F)C=C5)C=C43)=O)C[C@@H](C)NC2)CCOC1

Molecular Formula

C30H42FN5O3

Molecular Weight

539.68

Precautions

H302, H315, H319, H335

References & Citations

[1]Tomoko Smyth, et al. Abstract 1287: The dual IAP antagonist, ASTX660, increases the anti-tumor activity of NSC 125973 in preclinical models of triple-negative breast cancer in vivo. Cancer Res 2016;76 (14 Suppl) .