Rizatriptan (benzoate)

Rizatriptan benzoate is the agonist for 5-HT1B and 5-HT1D. Rizatriptan benzoate has a peripheral vasoconstrictive effect, penetrates the intact blood-brain barrier, and inhibits pain neurotransmission in the central nervous system[2].

Product Specifications

CAS Number

[145202-66-0]

Product Name Alternative

MK 462

UNSPSC

12352005

Hazard Statement

H360

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/rizatriptan-benzoate.html

Purity

99.93

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

CN(C)CCC1=CNC2=C1C=C(CN3N=CN=C3)C=C2.O=C(O)C4=CC=CC=C4

Molecular Formula

C22H25N5O2

Molecular Weight

391.47

Precautions

H360

References & Citations

[1]Sciberras DG, et al. Initial human experience with MK-462 (rizatriptan) : a novel 5-HT1D agonist. Br J Clin Pharmacol. 1997 Jan;43 (1) :49-54.|[2]Cumberbatch MJ, et al. Rizatriptan has central antinociceptive effects against durally evoked responses. Eur J Pharmacol. 1997 Jun 5;328 (1) :37-40.