ASP-8731
ASP8731 is a selective inhibitor of BACH1. ASP8731 inhibits inflammation and vaso-occlusion and induces fetal hemoglobin in sickle cell disease[1].
Product Specifications
CAS Number
[2488255-42-9]
UNSPSC
12352005
Target
Heme Oxygenase (HO)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/asp-8731.html
Concentration
10mM
Purity
98.42
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC(N=C(N2C)NC3=NC4=C(O3)C=CC=C4)=C2C=C1)NCCOCCO
Molecular Formula
C20H21N5O4
Molecular Weight
395.41
References & Citations
[1]Belcher JD, et, al. The BACH1 inhibitor ASP8731 inhibits inflammation and vaso-occlusion and induces fetal hemoglobin in sickle cell disease. Front Med (Lausanne) . 2023 Apr 18:10:1101501.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
Curated Selection
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