LRP1 Antibody

Rabbit Anti-Human LRP-1 Polyclonal

Product Specifications

Background

LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1) is a multifunctional endocytic receptor involved in lipid metabolism, protease clearance, and cell signaling. In the brain, LRP1 regulates amyloid-beta clearance, synaptic plasticity, and blood-brain barrier integrity. Dysregulation of LRP1 is associated with Alzheimer’s disease, where impaired Aβ clearance contributes to plaque accumulation and neurotoxicity. LRP1 also modulates neuroinflammatory responses and interacts with key signaling pathways, including Wnt and TGF-β. Its broad functional repertoire and role in maintaining neural homeostasis make LRP1 a critical target in neurodegenerative disease research and therapeutic development.

CAS Number

9007-83-4

Specifications

Detects 80 kDa. Band at 80 kDa is a membrane spanning subunit.

Product Name Alternative

LRP1, LRP-1, LRP-85, LRP-515, Alpha-2-macroglobulin receptor, A2MR, Apolipoprotein E receptor, Prolow-density lipoprotein receptor-related protein 1, CD91, LRPICD, APOER, APR

UNSPSC

12352203

UN Code

Non-hazardous

Hazard Statement

Non-hazardous

Gene ID

4035

Swiss Prot

Q07954

Accession Number

NP_002323.2

Cellular Locus

Cell Membrane | Single-Pass Type I Membrane Protein | Membrane | Coated Pit

Host

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthetic peptide from the N-terminal of Human Low-density lipoprotein receptor-related protein 1 (aa. 160-260)

Target

LRP-1

Clonality

Polyclonal

Conjugation

Unconjugated

Tissue Specificity

Most abundant in liver, brain and lung.

Type

Polyclonal

Applications

WB | IHC

Validated Applications

WB,IHC

Field of Research

Purification

Peptide Affinity Purified

Detection Range

A 1:1000 dilution of SPC-785 was sufficient for detection of LRP-1 in 15 µg of mouse Brain cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000) ; IHC (1:50) ; optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

PBS pH 7.4, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Shipping Conditions

Blue Ice or 4ºC

Storage Conditions

-20ºC

Specificity

Detects 80 kDa. Band at 80 kDa is a membrane spanning subunit.

Species

Human | Mouse | Rat

Location

Cell Membrane | Single-Pass Type I Membrane Protein | Membrane | Coated Pit

Immunogen Species

Human

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