PV-1019

PV-1019 (NSC 744039) is a potent, selective Chk2 inhibitor with an IC50 value of 24 nM. PV-1019 inhibits the Topotecan (HY-13768) -induced Chk2 autophosphorylation. PV-1019 inhibits IR-induced apoptosis[1].

Product Specifications

CAS Number

[1093793-05-5]

Product Name Alternative

NSC 744039

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Checkpoint Kinase (Chk)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pv-1019.html

Purity

99.30

Solubility

DMSO : 40 mg/mL (ultrasonic; adjust pH to 3 with 1 M HCl)

Smiles

O=C(C(N1)=CC2=C1C([N+]([O-])=O)=CC=C2)NC3=CC=C(/C(C)=N/NC(N)=N)C=C3

Molecular Formula

C18H17N7O3

Molecular Weight

379.37

Precautions

H302, H315, H319, H335

References & Citations

[1]Jobson AG, et, al. Cellular inhibition of checkpoint kinase 2 (Chk2) and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019 [7-nitro-1H-indole-2-carboxylic acid {4-[1- (guanidinohydrazone) -ethyl]-phenyl}-amide]. J Pharmacol Exp Ther. 2009 Dec;331 (3) :816-26.