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(Z)-Guggulsterone

Product Specifications

UNSPSC Description

(Z)-Guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. (Z)-Guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis[1]. (Z)-Guggulsterone is also a potent FXR antagonist. (Z)-Guggulsterone reduces ACE2 expression and SARS-CoV-2 infection[2].

Target Antigen

Akt; Angiotensin-converting Enzyme (ACE); Apoptosis; FXR; SARS-CoV; VEGFR

Type

Natural Products

Related Pathways

Anti-infection;Apoptosis;Metabolic Enzyme/Protease;PI3K/Akt/mTOR;Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/z-guggulsterone.html

Purity

99.30

Solubility

DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C)

Smiles

C[C@@]1(/C2=C/C)[C@](CC2=O)([H])[C@@]3([H])[C@]([C@@]4(C(CC3)=CC(CC4)=O)C)([H])CC1.[Z]

Molecular Weight

312.45

References & Citations

[1]Xiao D, et al. z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitro and in vivo. Mol Cancer Ther. 2008 Jan;7(1):171-80.|[2]Brevini T, et al. FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2. Nature. 2022 Dec 5.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-110066/Z-Guggulsterone-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-110066/Z-Guggulsterone-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

39025-23-5

Available Sizes

Curated Selection

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