Ethyl Caffeate

Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa. Ethyl caffeate suppresses NF-κB activation and its downstream inflammatory mediators, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and prostaglandin E2 (PGE2) in vitro or in mouse skin[1].

Product Specifications

CAS Number

[102-37-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

COX; NF-κB; NO Synthase; PGE synthase

Type

Natural Products

Related Pathways

Immunology/Inflammation; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/ethyl-caffeate.html

Purity

99.34

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O=C(OCC)/C=C/C1=CC=C(O)C(O)=C1

Molecular Formula

C11H12O4

Molecular Weight

208.21

Precautions

H302, H315, H319, H335

References & Citations

[1]Chiang YM, et al. Ethyl caffeate suppresses NF-kappaB activation and its downstream inflammatory mediators, iNOS, COX-2, and PGE2 in vitro or in mouse skin. Br J Pharmacol. 2005 Oct;146 (3) :352-63.