Dithizone

Dithizone can be toxic to pancreatic islet cells and cause experimental diabetes. Dithizone can be used for in vitro in vivo staining of transplanted islets and cytoplasmic granules of bone marrow cells. Dithizone can be used as a chelating agent and colorimetric indicator for the detection and extraction of various heavy metals, including lead and mercury, in analytical and biochemical applications. Dithizone forms stable colored complexes with metal ions and can be quantitatively analyzed by methods such as spectrophotometry[1][2].

Product Specifications

CAS Number

[60-10-6]

Product Name Alternative

Diphenylthiocarbazone

UNSPSC

12352200

Hazard Statement

H315, H319

Target

Biochemical Assay Reagents

Type

Biochemical Assay Reagents

Related Pathways

Others

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/dithizone.html

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

S=C(/N=N/C1=CC=CC=C1)NNC2=CC=CC=C2

Molecular Formula

C13H12N4S

Molecular Weight

256.33

Precautions

H315, H319

References & Citations

[1]Clark SA, et al. Staining and in vitro toxicity of dithizone with canine, porcine, and bovine islets. Cell Transplant. 1994 Jul-Aug;3 (4) :299-306.|[2]MCNARY WF Jr. Dithizone staining of myeloid granules. Blood. 1957 Jul;12 (7) :644-8.