Benzamide

Benzamide (Benzenecarboxamide) is a potent poly (ADP-ribose) polymerase (PARP) inhibitor. Benzamide has protective activity against both glutamate- and methamphetamine (METH) -induced neurotoxicity in vitro. Benzamide can attenuate the METH-induced dopamine depletions and exhibits neuroprotective activity in mice, also has no acute effect on striatal dopamine metabolism and does not reduce body temperature[1].

Product Specifications

CAS Number

[55-21-0]

Product Name Alternative

Benzenecarboxamide; Phenylamide

UNSPSC

12352005

Hazard Statement

H302, H341

Target

Endogenous Metabolite; PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/benzamide.html

Purity

99.82

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

NC(C1=CC=CC=C1)=O

Molecular Formula

C7H7NO

Molecular Weight

121.14

Precautions

H302, H341

References & Citations

[1]Cosi C, et al. Benzamide, an inhibitor of poly (ADP-ribose) polymerase, attenuates methamphetamine-induced dopamine neurotoxicity in the C57B1/6N mouse. Brain Res. 1996 Oct 7;735 (2) :343-8.