Yamogenin

Yamogenin (Neodiosgenin) is a diastereomer of diosgenin. Yamogenin antagonizes the activation of the liver X receptor (LXR) in luciferase ligand assay. Yamogenin inhibits triacylglyceride (TG) accumulation through the suppression of gene expression of fatty acid synthesis in HepG2 hepatocytes. Yamogenin is a steroidal saponin that can be obtained from plant species with in vitro cytotoxicity, antioxidant, and antimicrobial properties. Yamogenin induces cell death via the extrinsic and intrinsic way of apoptosis. Yamogenin inhibits protein denaturation with an IC50 of 1421.92 μg/mL. Yamogenin can be studied in research on gastric cancer[1][2].

Product Specifications

CAS Number

[512-06-1]

Product Name Alternative

Neodiosgenin

UNSPSC

12352005

Target

Apoptosis; Fatty Acid Synthase (FASN) ; LXR; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/yamogenin.html

Purity

99.86

Solubility

Ethanol : 8.33 mg/mL (ultrasonic)

Smiles

O[C@]1([H])CC2=CC[C@]3([H])[C@@](CC[C@@]4(C)[C@@]3([H])C[C@@]5([H])[C@]4([H])[C@@](C)([H])[C@@]6(CC[C@]([H])(C)CO6)O5)([H])[C@@]2(C)CC1

Molecular Formula

C27H42O3

Molecular Weight

414.62

References & Citations

[1]Moriwaki S, et al. Yamogenin in fenugreek inhibits lipid accumulation through the suppression of gene expression in fatty acid synthesis in hepatocytes.Biosci Biotechnol Biochem. 2014;78 (7) :1231-6.|[2]Stefanowicz-Hajduk, J., et al., (2024) . An In Vitro Study on the Cytotoxic, Antioxidant, and Antimicrobial Properties of Yamogenin-A Plant Steroidal Saponin and Evaluation of Its Mechanism of Action in Gastric Cancer Cells. International journal of molecular sciences, 25 (9), 4627.