Hydroxyurea

Hydroxyurea is a cell apoptosis inducer that inhibit DNA synthesis through inhibition of ribonucleotide reductase. Hydroxyurea shows anti-orthopoxvirus activity.

Product Specifications

CAS Number

[127-07-1]

Product Name Alternative

Hydroxycarbamide

UNSPSC

12352211

Hazard Statement

H340, H361

Target

Apoptosis; Autophagy; DNA/RNA Synthesis; HIV; Orthopoxvirus

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hydroxyurea.html

Purity

99.34

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

O=C(N)NO

Molecular Formula

CH4N2O2

Molecular Weight

76.05

Precautions

H340, H361

References & Citations

[1]Kovacic P, et al. Hydroxyurea (therapeutics and mechanism) : metabolism, carbamoyl nitroso, nitroxyl, radicals, cell signaling and clinical applications. Med Hypotheses. 2011 Jan;76 (1) :24-31.|[2]Watanapokasin Y, et al. In vivo and in vitro studies of fetal hemoglobin induction by hydroxyurea in beta-thalassemia/hemoglobin E patients. Exp Hematol. 2005 Dec;33 (12) :1486-92.|[3]Lori F, et al. Rationale for the use of hydroxyurea as an anti-human immunodeficiency virus drug. Clin Infect Dis. 2000 Jun;30 Suppl 2:S193-7.|[4]Lebensburger JD, et al. Hydroxyurea therapy requires HbF induction for clinical benefit in a sickle cell mouse model. Haematologica. 2010 Sep;95 (9) :1599-603.|[5]M B Slabaugh, et al. Hydroxyurea-resistant vaccinia virus: overproduction of ribonucleotide reductase. J Virol. 1986 Nov;60 (2) :506-14.