Bupropion morpholinol

Bupropion morpholinol (Hydroxy Bupropion) is a major metabolite of Bupropion. Bupropion morpholinol inhibits Dopamine, Norepinephrine transporters and the α4β2 nicotinic receptor in vitro. Bupropion morpholinol contributes to antidepressant and smoking cessation activities[1][2][3].

Product Specifications

CAS Number

[357399-43-0]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Dopamine Transporter; nAChR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/bupropion-morpholinol.html

Purity

99.66

Solubility

Ethanol : 20 mg/mL (ultrasonic; warming)

Smiles

OC1(C2=CC=CC(Cl)=C2)C(C)NC(C)(C)CO1

Molecular Formula

C13H18ClNO2

Molecular Weight

255.74

Precautions

H315, H319, H335

References & Citations

[1]Zhu AZX, et, al. CYP2B6 and bupropion's smoking-cessation pharmacology: the role of hydroxybupropion. Clin Pharmacol Ther. 2012 Dec;92 (6) :771-7.|[2]Damaj MI, et, al. Enantioselective effects of hydroxy metabolites of bupropion on behavior and on function of monoamine transporters and nicotinic receptors. Mol Pharmacol. 2004 Sep;66 (3) :675-82.|[3]Damaj MI, et, al. Effects of hydroxymetabolites of bupropion on nicotine dependence behavior in mice. J Pharmacol Exp Ther. 2010 Sep 1;334 (3) :1087-95.