Picoplatin

Picoplatin (AMD473) is a platinum-based antineoplastic agent. Picoplatin is specifically to circumvent thiol-mediated drug resistance by sterically hindering its reaction with glutathione (GSH) while still retaining the ability to form cytotoxic lesions with DNA[1].

Product Specifications

CAS Number

[181630-15-9]

Product Name Alternative

AMD473; ZD0473

UNSPSC

12352005

Hazard Statement

H290, H317, H334, H340, H350

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/picoplatin.html

Purity

98.5

Solubility

10 mM in DMSO

Smiles

[Cl-][Pt+2]([N]1=C(C)C=CC=C1)([NH3])[Cl-]

Molecular Formula

C6H10Cl2N2Pt

Molecular Weight

376.15

Precautions

H290, H317, H334, H340, H350

References & Citations

[1]J Holford, et al. In vitro circumvention of cisplatin resistance by the novel sterically hindered platinum complex AMD473. Br J Cancer. 1998;77 (3) :366-73.