TH1760

TH1760 is an inhibitor of NUDIX-type 15 (NUDT15) with an IC50 value of 25 nM. TH1760 sensitizes cells to 6-thioguanine by enhancing the accumulation of 6-thio- (d) GTP in nucleic acids. TH1760 enhances the anti-leukemia effect of thiopurine[1][2].

Product Specifications

CAS Number

[2567914-01-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/th1760.html

Solubility

10 mM in DMSO

Smiles

O=C1OC2=CC(S(=O)(N3CCN(CC3)C(C4=CC5=C(NC=C5)C=C4)=O)=O)=CC=C2N1

Molecular Formula

C20H18N4O5S

Molecular Weight

426.45

Precautions

H302, H315, H319

References & Citations

[1]Zhang SM, et al. Development of a chemical probe against NUDT15. Nat Chem Biol. 2020 Oct;16 (10) :1120-1128. |[2]Rehling D, et al. Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity. J Biol Chem. 2021 Jan-Jun;296:100568.