CB1R Allosteric modulator 3

CB1R Allosteric modulator 3 is a CB1R positive allosteric modulator. CB1R Allosteric modulator 3 has potent inhibition of cAMP and β-Arrestin with EC50 values of 0.018 μM and 1.241 μM, respectively[1].

Product Specifications

CAS Number

[2633686-36-7]

UNSPSC

12352005

Target

Arrestin; Cannabinoid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cb1r-allosteric-modulator-3.html

Purity

98.05

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

ClC1=C(C=CC=C1)C(C2=C(C3=CC=CC=C3)NC4=C2C=CC=C4)C[N+]([O-])=O

Molecular Formula

C22H17ClN2O2

Molecular Weight

376.84

References & Citations

[1]Peter C Schaffer, et al. Focused structure-activity relationship profiling around the 2-phenylindole scaffold of a cannabinoid type-1 receptor agonist-positive allosteric modulator: site-III aromatic-ring congeners with enhanced activity and solubility. Bioorg Med Chem. 2020 Nov 1;28 (21) :115727.