PKM2-IN-6
Product Specifications
UNSPSC Description
PKM2-IN-6 (compound 7d) is a potent and orally active PKM2 inhibitor with an IC50 value of 23 nM. PKM2-IN-6 induces apoptosis and cell cycle arrest at G2 phase. PKM2-IN-6 reduces the level of PKM1 and PKM2 at the mRNA level. PKM2-IN-6 shows anticancer activity and has the potential for the research of triple-negative breast cancer[1].
Target Antigen
Apoptosis; Pyruvate Kinase
Type
Reference compound
Related Pathways
Apoptosis;Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pkm2-in-6.html
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
COC1=CC=CC=C1NC2=NC(C3=CN=C4C=CC=CN43)=CS2
Molecular Weight
322.38
References & Citations
[1]Das R, et al. Mechanistic Investigation of Thiazole-Based Pyruvate Kinase M2 Inhibitor Causing Tumor Regression in Triple-Negative Breast Cancer. J Med Chem. 2024 Feb 26.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-157913/PKM2-IN-6-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-157913/PKM2-IN-6-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
771467-00-6
Available Sizes
Curated Selection
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