SBI-183
Product Specifications
UNSPSC Description
SBI-183 is an orally active inhibitor of QSOX1 (Kd: 20 μM). SBI-183 suppresses the proliferative and invasive phenotype of renal cancer cell lines, including triple negative breast cancer cell line, lung adenocarcinoma cell line and pancreatic ductal adenocarcinoma. SBI-183 inhibits tumor growth in two human xenograft mouse models of renal cell carcinoma in vivo [1].
Target Antigen
Transmembrane Glycoprotein
Type
Reference compound
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sbi-183.html
Smiles
O=C(C1=CC(OC)=CC=C1)NC2=CC=C(N3CCCC3)C=C2
Molecular Weight
296.36
References & Citations
[1]Fifield, et al. Molecular Inhibitor of QSOX1 Suppresses Tumor Growth In Vivo. Molecular cancer therapeutics. 2020, 19(1), 112–122.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-165245/SBI-183-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-165245/
Clinical Information
No Development Reported
CAS Number
625403-59-0
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