KRpep-2d (TFA)
Product Specifications
UNSPSC Description
KRpep-2d (TFA) is a potent K-Ras inhibitor and inhibits proliferation of K-Ras-driven cancer cells. KRpep-2d can be used for cancer research[1].
Target Antigen
Ras
Type
Peptides
Related Pathways
GPCR/G Protein;MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/krpep-2d-tfa.html
Purity
98.11
Solubility
10 mM in DMSO|H2O : 100 mg/mL (ultrasonic)
Smiles
O=C1N2[C@@](C(N[C@H](C(N[C@H](C(N[C@@](C(N[C@H](C(N[C@H](C(N[C@H](C(N3[C@](CCC3)([H])C(N[C@H](C(N[C@@H](CSSC[C@@H]1NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@@H](NC(C)=O)CCCNC(N)=N)=O)=O)=O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)C(C)C)=O)=O)CC(O)=O)=O)CC4=CC=C(C=C4)O)=O)CO)=O)([H])[C@@H](C)CC)=O)CC5=CC=C(C=C5)O)=O)CC(C)C)=O)([H])CCC2.OC(C(F)(F)F)=O
Molecular Weight
2675.03
References & Citations
[1]Niida A, et al. Investigation of the structural requirements of K-Ras(G12D) selective inhibitory peptide KRpep-2d using alanine scans and cysteine bridging. Bioorg Med Chem Lett. 2017 Jun 15;27(12):2757-2761.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P3277A/KRpep-2d-TFA-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P3277A/KRpep-2d-TFA-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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