Kobusin
Product Specifications
UNSPSC Description
Kobusin is a bisepoxylignan isolated from the Pnonobio biondii Pamp. Kobusin is an activator of CFTR and CaCCgie chloride channels and a inhibitor of ANO1/CaCC (calcium-activated chloride channel) channel[1][2].
Target Antigen
CFTR; Chloride Channel
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/kobusin.html
Purity
99.93
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=CC=C([C@H]2OC[C@]3([H])[C@@H](C4=CC=C(OCO5)C5=C4)OC[C@@]32[H])C=C1OC
Molecular Weight
370.40
References & Citations
[1]Yu Jiang , et al. Modulation of Chloride Channel Functions by the Plant Lignan Compounds Kobusin and Eudesmin. Front Plant Sci. 2015 Nov 25;6:1041.|[2]Xing Zhang, et al. Bioassay-guided isolation of bisepoxylignans from the flower buds of Magnolia biondii Pamp and their antiallergic effects. RSC Adv., 2017,7, 34236-34243.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N5101/Kobusin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N5101/Kobusin-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
36150-23-9
Available Sizes
Curated Selection
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