Kobusin

Kobusin is a bisepoxylignan isolated from the Pnonobio biondii Pamp. Kobusin is an activator of CFTR and CaCCgie chloride channels and a inhibitor of ANO1/CaCC (calcium-activated chloride channel) channel[1][2].

Product Specifications

CAS Number

[36150-23-9]

UNSPSC

12352005

Hazard Statement

H302, H361, H372, H410

Target

CFTR; Chloride Channel

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/kobusin.html

Purity

99.93

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=CC=C([C@H]2OC[C@]3([H])[C@@H](C4=CC=C(OCO5)C5=C4)OC[C@@]32[H])C=C1OC

Molecular Formula

C21H22O6

Molecular Weight

370.40

Precautions

H302, H361, H372, H410

References & Citations

[1]Yu Jiang , et al. Modulation of Chloride Channel Functions by the Plant Lignan Compounds Kobusin and Eudesmin. Front Plant Sci. 2015 Nov 25;6:1041.|[2]Xing Zhang, et al. Bioassay-guided isolation of bisepoxylignans from the flower buds of Magnolia biondii Pamp and their antiallergic effects. RSC Adv., 2017,7, 34236-34243.