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VPS35 Antibody: RPE

Mouse Anti-Human VPS35 Monoclonal IgG1

Product Specifications

Background

Vacuolar Protein Sorter-35 (VPS35) is a component of the retromer complex, which is essential for endosome-to-Golgi retrieval of membrane proteins. VPS35 mutations such as D620N have been linked to Parkinson’s Disease (PD) (1,2) and affect retromer function, protein homeostasis, and mitochondria (3).

Specifications

Detects ~92 kDa.

Product Name Alternative

Vacuolar protein sorting-associated protein 35, MEM3, PARK17, VPS35 retromer complex component, maternal-embryonic 3, vesicle protein sortin 35, TCCCTA00141, FLJ10752

Synonyms

VPS35 Antibody, Clone 8A3: RPE

UNSPSC

12352203

Gene ID

55737

Swiss Prot

Q96QK1

Accession Number

NP_060676.2

Cellular Locus

Endosome | Lysosome | Vesicles | Cytoplasm | Membrane

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Full length recombinant human VSP35

Target

VPS35

Clonality

Monoclonal

Isotype

IgG1

Clone

8A3

Conjugation

RPE

Tissue Specificity

Ubiquitous. Highly expressed in brain, colon, heart, kidney, ovary, placenta, skeletal muscle, small intestine, testis, thymus.

Validated Applications

WB,IHC,ICC/IF

Purification

Protein G Purified

Limit Of Detection

A 1:1000 dilution of SMC-604 was sufficient for detection of VPS35 in 10 µg of SH-SY5Y by ECL immunoblot analysis using Goat Anti-Mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000); ICC/IF (1:200); IP (1:200); IHC (1:100); optimal dilutions for assays should be determined by the user.; optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

95.64mM Phosphate, 2.48mM MES and 2mM EDTA

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Vilarino-Guell, C. et al. (2011) Am J Hum Genet 89:162–167 2. Zimprich, A. et al. (2011) Am J Hum Genet 89:168–175 3. Rahman, A.A., Morrison, B.E. (2019) Neurosci 401:1-10.

Product Datasheet

https://cdn.gentaur.com/products/400/4294467/datasheet/smc-604d-rpe.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4294467/msds/smc-604d-rpe.pdf

CAS Number

9007-83-4

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