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KDEL Antibody: ATTO 594

Mouse Anti-KDEL Monoclonal IgG1

Product Specifications

Background

The endoplasmic reticulum is part of a protein sorting pathway, or in essence, the transportation system of the eukaryotic cell. The majority of endoplasmic reticulum resident proteins are retained in the endoplasmic reticulum through a retention motif. This motif is composed of four amino acids at the C-terminal end of the protein sequence. The most common retention sequence is KDEL (lys-asp-glu-leu). Grp78 and Grp94 and PDI all share the C-terminal KDEL sequence. The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER.

Specifications

Detects KDEL tagged proteins.

Product Name Alternative

KDEL Antibody, Lys Asp Glu Leu Antibody, Lys-Asp-Glu-Leu (KDEL) Antibody, Lys-Asp-Glu-Leu Antibody, Lysine-aspartic acid-glutamate-leucine Antibody

Synonyms

KDEL Antibody, Clone 2C1: ATTO 594

UNSPSC

12352203

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

KDEL peptide (C-AVKDEL -COOH) conjugated at the N-terminal to Bovine Serum Albumin (BSA)

Target

KDEL

Clonality

Monoclonal

Isotype

IgG1

Clone

2C1

Conjugation

ATTO 594

Validated Applications

IHC,ICC/IF

Purification

Protein G Purified

Limit Of Detection

A 1:1000 dilution of SMC-539 was sufficient for detection of KDEL in 10 µg of HeLa cell lysates by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000); IHC (1:25); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

640.91mM DMSO, 136.36mM Ethanolamine, 9.09mM Sodium Bicarbonate in 90.9% PBS

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Ozawa K., et al. (2008) Mol Pharmacol. 74:1610. 2. Austin R.C., et al. (2003) J Biol Chem. 278: 17438.

Product Datasheet

https://cdn.gentaur.com/products/400/4293724/datasheet/smc-539d-a594.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4293724/msds/smc-539d-a594.pdf

CAS Number

9007-83-4

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