Alpha Synuclein Antibody, Clone 4F1

Alpha-synuclein (SNCA) is a neuronal protein predominantly expressed in the brain, where it is highly concentrated at presynaptic nerve terminals, suggesting a key role in synaptic transmission and plasticity (1) . In addition to its synaptic localization, alpha-synuclein is abundantly expressed in mitochondria-rich brain regions, including the olfactory bulb, hippocampus, striatum, and thalamus, implicating it in mitochondrial function and energy metabolism (2) . Functionally, alpha-synuclein has been shown to interact significantly with tubulin (3), indicating a potential role as a microtubule-associated protein involved in cytoskeletal organization and intracellular transport. This interaction may be critical for maintaining neuronal structure and function, particularly in long-range axonal projections. Importantly, alpha-synuclein is essential for normal cognitive development. Genetic or functional inactivation of SNCA has been associated with impairments in spatial learning and working memory, underscoring its role in higher-order brain functions (4) . Given its physiological importance and pathological aggregation in disorders such as Parkinson’s disease and dementia with Lewy bodies, alpha-synuclein remains a focal point in neurodegenerative disease research. Understanding its normal function and mechanisms of misfolding is vital for developing targeted diagnostics and therapeutics.

Binds multiple linear epitopes within human alpha synuclein: 21-70 aa, 61-90 aa, and 101-140 aa, determined using Dot blot and ELISA with corresponding peptides. Detects ~14 kDa band corresponding to Alpha synuclein. Band at ~40 kDa is a trimer.

Alpha Synuclein, α-Synuclein, SNCA, Snca, SYN, alphaSYN, NACP, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, Parkinson disease familial 1, PARK1, PARK 1, PARK4, PARK 4, Parkinson disease (autosomal dominant, Lewy body) 4

Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals.

Neuroscience | Neurodegeneration | Alzheimer's Disease | Tangles & Tau | Neuroscience | Neurodegeneration | Parkinson's Disease | Synuclein | Neuroscience | Neurodegeneration | Multiple System Atrophy

A 1:1000 dilution of SMC-533 was sufficient for detection of Alpha Synuclein in 15 µg of human brain cell lysate by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

1. “Genetics Home Reference: SNCA”. US National Library of Medicine. (2013). 2. Zhang L., et al. (2008) Brain Res. 1244: 40-52. 3. Alim M.A., et al. (2002) J Biol Chem. 277(3): 2112-2117. 4. Kokhan V.S., Afanasyeva M.A., Van'kin G. (2012) Behav. Brain. Res. 231(1): 226-230. 5. Spillantini M.G., et al. (1997) Nature. 388(6645): 839-840. 6. Mezey E., et al. (1998) Nat Med. 4(7): 755-757.

Binds multiple linear epitopes within human alpha synuclein: 21-70 aa, 61-90 aa, and 101-140 aa, determined using Dot blot and ELISA with corresponding peptides. Detects ~14 kDa band corresponding to Alpha synuclein. Band at ~40 kDa is a trimer.

1. “Genetics Home Reference: SNCA”. US National Library of Medicine. (2013) . 2. Zhang L., et al. (2008) Brain Res. 1244: 40-52. 3. Alim M.A., et al. (2002) J Biol Chem. 277 (3) : 2112-2117. 4. Kokhan V.S., Afanasyeva M.A., Van'kin G. (2012) Behav. Brain. Res. 231 (1) : 226-230. 5. Spillantini M.G., et al. (1997) Nature. 388 (6645) : 839-840. 6. Mezey E., et al. (1998) Nat Med. 4 (7) : 755-757.