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Dityrosine Antibody

Mouse Anti-Dityrosine (DT) Monoclonal IgG1

Product Specifications

Background

ROS such as hydrogen peroxide (H2O2), superoxide, and hydroxyl radicals can react with both the backbone and the side chains of proteins, leading to backbone cleavage and side-chain modifications, respectively. Peroxidases, UV radiation, and hydroxyl radicals catalyze the formation of tyrosyl radicals which then react to form cross-links between proteins (1). This produces dityrosine, a metabolically stable biomarker of protein oxidation (2).

Specifications

Specific for dityrosine modified proteins. Does not cross-react with 3,5-dibromotyrosine or bromotyrosine modified proteins.

Product Name Alternative

Dityrosine Antibody, Dityrosine (DT) Antibody, DT Antibody, DY Antibody

Synonyms

Dityrosine Antibody, Clone 10A6

UNSPSC

12352203

Host

Mouse

Species Reactivity

Species Independent

Immunogen

Synthetic Dityrosine conjugated to Keyhole Limpet Hemocyanin (KLH).

Target

Dityrosine

Clonality

Monoclonal

Isotype

IgG1

Clone

10A6

Conjugation

Unconjugated

Validated Applications

WB,ICC/IF,FACS,FCM,ELISA

Purification

Protein G Purified

Limit Of Detection

A 1:1000 dilution of SMC-521 was sufficient for detection of dityrosine in 1 µg of Dityrosine conjugated to BSA by ECL immunoblot analysis using Goat Anti-Mouse IgG:HRP as the secondary Antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000); ICC/IF (1:50); FACS (1:50); FCM (1:50); ELISA (1:1000); optimal dilutions for assays should be determined by the user.

Weight

0.012

Buffer

PBS pH7.4, 50% glycerol, 0.09% sodium azide

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Malencik, D. A., Anderson, S. R. (2003) Amino Acids. 25(3-4):233-247. 2. Giulivi, C., Davies, K. J. A. (2001) J Biol Chem. 276, 24129-24136.

Product MSDS

https://cdn.gentaur.com/products/400/4293469/msds/smc-521s.pdf

CAS Number

9007-83-4

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