Malondialdehyde Antibody: RPE
Mouse Anti-Malondialdehyde (MDA) Monoclonal IgG1
Product Specifications
Background
Malondialdehyde (MDA) is the biomarker in greatest diagnostic use, due to its molecular stability. This three-carbon, low-molecular weight aldehyde has a strong affinity for amino acids, which results in adduct formation to both free amino acids and proteins. Increased MDA levels have been found at correlating levels in breast cancer, and lung cancer patients. Other diseased states with elevated MDA levels include diabetes and Alzheimer’s disease. Multiple laboratory techniques exist for quantification of MDA levels, including the thiobarbituric acid reactive substances (TBARS) assay. In addition to use as a biomarker, MDA has been shown to have mutagenic effects on tissues themselves as adduct formation can result in DNA cross-linking.
Specifications
Specific for Malondialdehyde conjugated proteins. Does not detect free Malondialdehyde. Does not cross-react with Acrolein, Crotonaldehyde, Hexanoyl Lysine, 4-Hydroxy-2-hexenal, 4-Hydroxy nonenal, or Methylglyoxal modified proteins.
Product Name Alternative
Malondialdehyde Antibody, MDA Antibody, Malondialdehyde (MDA) Antibody, Malonic aldehyde Antibody Propanedial Antibody, 1,3-Propanedial Antibody, Malonaldehyde Antibody
Synonyms
Malondialdehyde Antibody, Clone 11E3: RPE
UNSPSC
12352203
Host
Mouse
Species Reactivity
Species Independent
Immunogen
Synthetic Malondialdehyde modified Keyhole Limpet Hemocyanin (KLH).
Target
Malondialdehyde
Clonality
Monoclonal
Isotype
IgG1
Clone
11E3
Conjugation
RPE
Validated Applications
WB,IHC,ICC/IF
Purification
Protein G Purified
Limit Of Detection
A 1:1000 dilution of SMC-515 was sufficient for detection of Malondialdehyde in 2 µg of Malondialdehyde conjugated to BSA by ECL immunoblot analysis using Goat Anti-Mouse IgG:HRP as the secondary Antibody.
Concentration
1 mg/ml
Dilution
WB (1:1000); ICC/IF (1:50); ELISA (1:1000); IHC (1:100); optimal dilutions for assays should be determined by the user.
Weight
0.1
Buffer
95.64mM Phosphate, 2.48mM MES and 2mM EDTA
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Product Datasheet
https://cdn.gentaur.com/products/400/4293317/datasheet/smc-515d-rpe.pdf
Product MSDS
https://cdn.gentaur.com/products/400/4293317/msds/smc-515d-rpe.pdf
CAS Number
9007-83-4
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