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4-Hydroxynonenal Antibody: FITC

Mouse Anti-4-Hydroxynonenal (4-HNE) Monoclonal IgG1

Product Specifications

Background

4-Hydroxy-2-nonenol (4-HNE) is an unsaturated aldehyde derived from lipid peroxidation. 4-HNE is an electrophile and reacts with protein nucleophiles such as cysteine, histine, and lysine (1). Low levels of 4-HNE promote cell survival via cellular antioxidant induction whereas higher levels lead to autophagy, apoptosis, and ultimately necrosis. 4-HNE has been linked to Alzheimer's disease, Parkinson's disease, cancer, cardiovascular diseases, diabetes, and liver disease.

Specifications

Specific for 4-Hydroxynonenal (4-HNE) modified proteins. Does not detect free 4-Hydroxynonenal. Does not cross-react with 4-Hydroxy-2-hexenal, Acrolein, Crotonaldehyde, Hexanoyl Lysine, Malondialdehyde, or Methylglyoxal modified proteins.

Product Name Alternative

4-Hydroxynonenal Antibody, 4-Hydroxy Nonenal (4-HNE) Antibody, 4-Hydroxy Nonenal Antibody, 4-HNE Antibody, 4-hydroxy Hexenal Antibody, HNE Antibody, 4-hydroxy-2-nonenal Antibody

Synonyms

4-Hydroxynonenal Antibody, Clone 12F7: FITC

UNSPSC

12352203

Host

Mouse

Species Reactivity

Species Independent

Immunogen

Synthetic 4-Hydroxynonenal modified Keyhole Limpet Hemocyanin (KLH).

Target

4-Hydroxynonenal

Clonality

Monoclonal

Isotype

IgG1

Clone

12F7

Conjugation

FITC

Validated Applications

IHC,ICC/IF

Purification

Protein G Purified

Limit Of Detection

A 1:1000 dilution of SMC-511 was sufficient for detection of 4-Hydroxynonenal in 0.5 µg of 4-Hydroxynonenal conjugated to BSA by ECL immunoblot analysis using Goat Anti-Mouse IgG:HRP as the secondary Antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000); ICC/IF (1:50); ELISA (1:1000); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

640.91mM DMSO, 136.36mM Ethanolamine, 9.09mM Sodium Bicarbonate in 90.9% PBS

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Peterson, D., Doorn, J. (2004) Free Radic Biol Med. 37(7):937-945.

Product Datasheet

https://cdn.gentaur.com/products/400/4293213/datasheet/smc-511d-fitc.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4293213/msds/smc-511d-fitc.pdf

CAS Number

9007-83-4

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