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NPAS4 Antibody: RPE

Mouse Anti-Rat NPAS4 Monoclonal IgG1

Product Specifications

Background

NPAS4 belongs to the Per-Arnt-Sim family of neuronal specific transciption factors, all involved in the development and maintenance of learning and memory pathways (1). NPAS4 is a transcription factor that regulates the formation and maintenance of inhibitory synapses, and can activate the CNS midline enhancer element and the expression of the drebrin gene. Deregulation has been to be associated with developmental disorders such as schizophrenia and autism (2).

Specifications

Detects ~90kDa.

Product Name Alternative

Neuronal PAS domain-containing protein 4 Antibody, Neuronal PAS4 Antibody, Class E basic helix-loop-helix protein 79 Antibody, HLH-PAS transcription factor NXF Antibody, PAS domain-containing protein 10 Antibody, Limbic-enhanced PAS protein Antibody, bHLHe79 Antibody, PASD10 Antibody and LE-PAS Antibody

Synonyms

NPAS4 Antibody, Clone N408/79: RPE

UNSPSC

12352203

Gene ID

266734

Swiss Prot

Q8CJH6

Accession Number

NP_705890.1

Cellular Locus

Cytoplasm | Nucleus

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein amino acids 597-802 (C-terminus) of rat Npas4.

Target

NPAS4

Clonality

Monoclonal

Isotype

IgG1

Clone

N408/79 (Formerly sold as S408-79)

Conjugation

RPE

Tissue Specificity

Highly expressed in the brain, with lower expression found in endocrine tissue.

Validated Applications

WB,IHC,ICC/IF

Purification

Protein G Purified

Limit Of Detection

A 1:100 dilution of SMC-495 was sufficient for detection of NPAS4 in 20 µg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000), ICC/IF(1:100); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

95.64mM Phosphate, 2.48mM MES and 2mM EDTA

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Zhaohui Z., et al. (2014) Exp Ther Med. 7(4): 1045-1049. 2. Coutellier L., et al. (2012) Plos One. 7(9): e46604.

Product Datasheet

https://cdn.gentaur.com/products/400/4292917/datasheet/smc-495d-rpe.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4292917/msds/smc-495d-rpe.pdf

CAS Number

9007-83-4

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