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GABA A Receptor Alpha 5 Antibody: FITC

Mouse Anti-Human GABA A Receptor Alpha5 Monoclonal IgG1

Product Specifications

Background

The GABA A Receptor is a member of the superfamily of fast acting ligand-gated ion channels. The individual subunits of these receptors have similar sequences and structural features (1). GABA-A receptors are the major fast inhibitory neurotransmitter gated ion channels in the brain (2). Recent research shows their usage in investigating side effects of drugs and the effects of learning and memory. Inverse agonists of the Alpha5 subunit may be useful in the treatment of Alzheimer's Disease (3).

Specifications

Detects ~55kDa. Does not cross-react with GABA A Receptor Alpha2 or other GABA-A Receptors based on KO validation data.

Product Name Alternative

Gamma-aminobutyric acid receptor subunit alpha-5 Antibody, GABA(A) Receptor subunit Alpha-5 Antibody, Gabra5 Antibody

Synonyms

GABA A Receptor Alpha 5 Antibody, Clone N415/24: FITC

UNSPSC

12352203

Gene ID

2558

Swiss Prot

P31644

Accession Number

NP_000801.1

Cellular Locus

Cell Junction | Synapse | Postsynaptic Cell Membrane | Cell Membrane

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein amino acids 368-419 (last cytoplasmic domain before extracellular C-terminus) of human GABA A Receptor Alpha5.

Target

GABA A Receptor

Clonality

Monoclonal

Isotype

IgG1

Clone

N415/24 (Formerly sold as S415-24)

Conjugation

FITC

Validated Applications

IHC,ICC/IF

Purification

Protein G Purified

Limit Of Detection

A 1:100 dilution of SMC-494 was sufficient for detection of GABA-A R, Alpha5 in 20 µg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

640.91mM DMSO, 136.36mM Ethanolamine, 9.09mM Sodium Bicarbonate in 90.9% PBS

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Bracamontes J.R. and Steinbach J.H. (2008) J Bio Chem. 283: 26128-26136. 2. Macdonald R.L., Olsen R.W. (1993) Annu Rev Neurosci. 17: 569-602. 3. Hengen K.B., et al. (2012) PLoS One. 7(1): e30608.

Product Datasheet

https://cdn.gentaur.com/products/400/4292888/datasheet/smc-494d-fitc.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4292888/msds/smc-494d-fitc.pdf

CAS Number

9007-83-4

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