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Nav beta3 Antibody: APC

Mouse Anti-Rat Nav beta 3 Monoclonal IgG2B

Product Specifications

Background

Nav Beta 3 (SCN3B) belongs to the voltage-gated sodium channel group, and modulates channel gating kinetics. It inactivates the sodium channel opening more slowly than its Beta1 subunit. It is also unique in causing persistent sodium currents which are thought to amplify summation of synaptic imputs which is likely to increase the excitability of specific neurons to their individual inputs (2). Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (1, 2). Defects in SCN3B are the cause of Brugada syndrome (3).

Specifications

Detects ~40kDa. Does not cross-reat with NavBeta1, Navbeta2, or Navbeta4.

Product Name Alternative

Sodium channel subunit beta-3 Antibody, Scn3b Antibody, KIAA1158 Antibody

Synonyms

NaVbeta3 Antibody, Clone N396/29: APC

UNSPSC

12352203

Gene ID

245956

Swiss Prot

Q9JK00

Accession Number

NP_620797.1

Cellular Locus

Membrane

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein amino acids 1-215 (full-length) of rat NavBeta3

Target

NaVbeta3

Clonality

Monoclonal

Isotype

IgG2B

Clone

N396/29 (Formerly sold as S396-29)

Conjugation

APC

Validated Applications

IHC,ICC/IF

Purification

Protein G Purified

Limit Of Detection

A 1:100 dilution of SMC-490 was sufficient for detection of NavBeta3 in 20 µg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

95.64mM Phosphate, 2.48mM MES and 2mM EDTA

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Genes and mapped phenotypes. (n.d.). Retrieved March 26, 2015, from http://www.ncbi.nlm.nih.gov/gene/?term=Q9jK00 2. Qu Y., et al. (2001) Mol Cell Neurosci. 18(5): 570-580. 3. Ishikawa T., et al. (2013) Circ J. 77(4): 956-967.

Product Datasheet

https://cdn.gentaur.com/products/400/4292780/datasheet/smc-490d-apc.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4292780/msds/smc-490d-apc.pdf

CAS Number

9007-83-4

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