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Ankyrin R Antibody

Mouse Anti-Human Ankyrin R Monoclonal IgG2B

Product Specifications

Background

Ankyrins are a family of adaptor proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane skeleton (1). Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral membrane proteins. This linkage is required to maintain the integrity of the plasma membranes and to anchor specific ion channels, ion exchangers and ion transporters in the plasma membrane. Ankyrin R, or Ank1, was first discovered in erythrocyres, but has since also been located in the brain and muscles. Mutations are associated with hereditary spehrocytosis and alzheimer's diease (2).

Specifications

Detects ~200kDa. Does not cross-react with Ankyrin-B or Ankyrin-G.

Product Name Alternative

Ankyrin-R Antibody, Ankyrin-1 Antibody, Erythrocyte Ankyrin Antibody, ANK-1 Antibody, ANK Antibody, rCG_43073 Antibody

Synonyms

Ankyrin R Antibody, Clone N388A/10

UNSPSC

12352203

Gene ID

286

Swiss Prot

P16157

Accession Number

NP_000028.3

Cellular Locus

Cytoplasm | Cytoskeleton | Myofibril | Sarcomere | M line

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein amino acids 1-1881 (full-length) of human Ankyrin-R

Target

Ankyrin R

Clonality

Monoclonal

Isotype

IgG2B

Clone

N388A/10 (Formerly sold as S388A-10)

Conjugation

Unconjugated

Validated Applications

WB,IHC,ICC/IF

Purification

Protein G Purified

Limit Of Detection

A 1:100 dilution of SMC-487 was sufficient for detection of Ankyrin R in 20 µg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000); optimal dilutions for assays should be determined by the user.

Weight

0.012

Buffer

PBS pH7.4, 50% glycerol, 0.1% sodium azide

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Bennett V., Baines A.J. (2001) Physiol. Rev. 81 (3): 1353–92. 2. Genes and mapped phenotypes. (n.d.). Retrieved April 21, 2015, from http://www.ncbi.nlm.nih.gov/gene/286

Product MSDS

https://cdn.gentaur.com/products/400/4292719/msds/smc-487s.pdf

CAS Number

9007-83-4

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