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GABA-A Receptor Alpha 2 Antibody: RPE

Mouse Anti-Rat GABA-A Receptor Alpha2 Monoclonal IgG1

Product Specifications

Background

The GABA-A receptor is a member of the superfamily of fast acting ligand-gated ion channels. The individual subunits of these receptors have similar sequences and structural features (1). GABA-A receptors are the major fast inhibitory neurotransmitter gated ion channels in the brain (2).

Specifications

Detects ~55kDa. Does not cross-react with GABA-A Receptor Alpha1.

Product Name Alternative

GABA A receptor subunit alpha 2 Antibody, GABRA2 Antibody, Gamma aminobutyric acid A receptor Alpha 2 Antibody, GBRA2_Human Antibody

Synonyms

GABA-A Receptor Alpha 2 Antibody, Clone N399/19: RPE

UNSPSC

12352203

Gene ID

289606

Swiss Prot

P23576

Accession Number

NP_001129251.1

Cellular Locus

Cytoplasm

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein amino acids 350-385 (Cytoplasmic C-terminus) of rat GABA-A Receptor Alpha2

Target

GABA A Receptor

Clonality

Monoclonal

Isotype

IgG1

Clone

N399/19 (Formerly sold as S399-19)

Conjugation

RPE

Validated Applications

WB,IHC,ICC/IF

Purification

Protein G Purified

Limit Of Detection

A 1:100 dilution of SMC-486 was sufficient for detection of GABA-A R, Alpha2 in 20 µg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

95.64mM Phosphate, 2.48mM MES and 2mM EDTA

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Bracamontes J.R. and Steinbach J.H. (2008) J Bio Chem. 283: 26128-26136. 2. Macdonald R.L., Olsen R.W. (1993) Annu Rev Neurosci. 17: 569-602.

Product Datasheet

https://cdn.gentaur.com/products/400/4292692/datasheet/smc-486d-rpe.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4292692/msds/smc-486d-rpe.pdf

CAS Number

9007-83-4

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