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GABA-A Receptor Alpha 2 Antibody: ATTO 390

Mouse Anti-Rat GABA-A Receptor Alpha2 Monoclonal IgG1

Product Specifications

Background

The GABA-A receptor is a member of the superfamily of fast acting ligand-gated ion channels. The individual subunits of these receptors have similar sequences and structural features (1). GABA-A receptors are the major fast inhibitory neurotransmitter gated ion channels in the brain (2).

Specifications

Detects ~55kDa. Does not cross-react with GABA-A Receptor Alpha1.

Product Name Alternative

GABA A receptor subunit alpha 2 Antibody, GABRA2 Antibody, Gamma aminobutyric acid A receptor Alpha 2 Antibody, GBRA2_Human Antibody

Synonyms

GABA-A Receptor Alpha 2 Antibody, Clone N399/19: ATTO 390

UNSPSC

12352203

Gene ID

289606

Swiss Prot

P23576

Accession Number

NP_001129251.1

Cellular Locus

Cytoplasm

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein amino acids 350-385 (Cytoplasmic C-terminus) of rat GABA-A Receptor Alpha2

Target

GABA A Receptor

Clonality

Monoclonal

Isotype

IgG1

Clone

N399/19 (Formerly sold as S399-19)

Conjugation

ATTO 390

Validated Applications

IHC,ICC/IF

Purification

Protein G Purified

Limit Of Detection

A 1:100 dilution of SMC-486 was sufficient for detection of GABA-A R, Alpha2 in 20 µg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

640.91mM DMSO, 136.36mM Ethanolamine, 9.09mM Sodium Bicarbonate in 90.9% PBS

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Bracamontes J.R. and Steinbach J.H. (2008) J Bio Chem. 283: 26128-26136. 2. Macdonald R.L., Olsen R.W. (1993) Annu Rev Neurosci. 17: 569-602.

Product Datasheet

https://cdn.gentaur.com/products/400/4292671/datasheet/smc-486d-a390.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4292671/msds/smc-486d-a390.pdf

CAS Number

9007-83-4

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