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beta 4 Spectrin Antibody: APC

Mouse Anti-Human beta 4 Spectrin Monoclonal IgG1

Product Specifications

Background

Spectrin is the major constituent of the cytoskeletal network underlying the erthrocyte plasma membrane and determines cell shape, arrangement of transmembrane proteins and organization of organelles. It is expressed at very low levels in many tissues, with the strongest expression in the cerebellum, spinal cord, stomach, pituitary gland, liver, pancreas, salivary gland, kidney, bladder and heart (1). Spectrin beta 4 is a non-erythrocyte member, and is expressed in the brain and pancreatic islets and localisted to the nuclear matrix, cytoplasmic vesicles and PML nuclear bodies. Beta4 spectrins are also essential for membrane stability and the molecular organization of the nodes of Ranvier (2).

Specifications

Detects ~>200kDa. Does not cross react with other Beta-spectrins

Product Name Alternative

BetaIV-spectrin sigma1 Antibody, Non-erythrocytic spectrin beta chain 4 Antibody, Non-erythroidspectrin beta chain 3 Antibody, SPTBN4 Antibody, SPTBN3 Antibody, Spnb4 Antibody, KIAA1642 Antibody, EMBL BAB83243.1 Antibody, Ensembl ENSRNOP00000028393 Antibody

Synonyms

beta 4 Spectrin Antibody, Clone N393/2: APC

UNSPSC

12352203

Gene ID

57731

Swiss Prot

Q9H254

Accession Number

NP_066022.2

Cellular Locus

Cytoplasm | Cytoskeleton | Cytoplasm | Cell Cortex

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein amino acids 1621-1832 (C-terminal repeats 14 to 15) of human Beta4-spectrin

Target

beta 4 Spectrin

Clonality

Monoclonal

Isotype

IgG1

Clone

N393/2 (Formerly sold as S393-2)

Conjugation

APC

Validated Applications

IHC,ICC/IF

Purification

Protein G Purified

Limit Of Detection

A 1:100 dilution of SMC-484 was sufficient for detection of Beta 4 Spectrin in 20 µg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

95.64mM Phosphate, 2.48mM MES and 2mM EDTA

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Genes and mapped phenotypes. (n.d.). Retrieved March 12, 2015, from http://www.ncbi.nlm.nih.gov/gene/57731 2. Yang Y., Lacas-Gervais S., Morest D.K., Solimena M., and Rasband M.N. (2004) J Neurosci. 24(33): 7230-7240.

Product Datasheet

https://cdn.gentaur.com/products/400/4292630/datasheet/smc-484d-apc.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4292630/msds/smc-484d-apc.pdf

CAS Number

9007-83-4

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