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Neuroligin 3 Antibody

Mouse Anti-Rat Neuroligin 3 Monoclonal IgG1

Product Specifications

Background

Neuroligins are Type I membrane proteins enriched in synaptic plasma membranes and clustered in synaptic clefts and postsynaptic densities. They have been characterized as neuronal cell surface proteins and are thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. They play a major role in the formation or maintenance of synaptic junctions. They are also thought to be involved in the specification of excitatory synapses. Neuroligins interact with beta-neurexins and this interaction is involved in the formation of functional synapses.

Specifications

Detects ~110kDa. Does not cross-react with Neuroligin-1, -2, -4 or -4.

Product Name Alternative

Gliotactin homolog Antibody, Neuroligin-3 Antibody, Nlgn3 Antibody, NLGN3_HUMAN Antibody

Synonyms

Neuroligin 3 Antibody, Clone N110/29

UNSPSC

12352203

Gene ID

171297

Swiss Prot

Q62889

Accession Number

AAA97871

Cellular Locus

Cell Membrane | Cell Junction | Synapse

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein amino acids 730-848 (intracellular C-terminus) of rat Neuroligin-3. Mouse: 99% identity (118/119 amino acids identical). Human: 98% identity (116/119 amino acids identical) ~60% identity with Neuroligin-1. ~40% identity with Neuroligin-2.

Target

Neuroligin 3

Clonality

Monoclonal

Isotype

IgG1

Clone

N110/29 (Formerly sold as S110-29)

Conjugation

Unconjugated

Validated Applications

WB,IHC,ICC/IF

Purification

Protein G Purified

Limit Of Detection

1 µg/ml of SMC-471 was sufficient for detection of Neuroligin 3 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000); optimal dilutions for assays should be determined by the user.

Weight

0.012

Buffer

PBS pH7.4, 50% glycerol, 0.1% sodium azide

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Product MSDS

https://cdn.gentaur.com/products/400/4292319/msds/smc-471s.pdf

CAS Number

9007-83-4

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