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Neuroligin 1 Antibody

Mouse Anti-Rat Neuroligin 1 Monoclonal IgG1

Product Specifications

Background

Neuroligin-1 is a neuronal cell surface protein belonging to the type-B carboxylesterase/lipase family. It is a necessary component in the maturation of excitatory synapses for their normal, functional development, and is necessary to the regulation of synaptic plasticity and the development of long-term memory within the adult amygdala in mammals. It is believed to participate in cell-cell-interaction through the assembly of intracellular junction by the binding of beta-neurexins, and may also be a factor in the maintenance and assembly of synaptic junctions. It is also thought to have involvement in excitatory synaptic specification. Within brain tissue, Neuroligin-1 is primarily observed in neurons and spinal cord.

Specifications

Detects ~120kDa. Does not cross-react with other Neuroligins.

Product Name Alternative

NLG 1 Antibody, KIAA1070 Antibody, MGC45115 Antibody, Neuroligin-1 Antibody, NL1 Antibody, NLG1 Antibody, Nlgn1 Antibody

Synonyms

Neuroligin 1 Antibody, Clone N97A/31

UNSPSC

12352203

Gene ID

116647

Swiss Prot

Q62765

Accession Number

NP_446320.1.

Cellular Locus

Cell Membrane | Cell Junction | Synapse | Postsynaptic Cell Membrane | Postsynaptic Density

Host

Mouse

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein amino acids 718-843 (cytoplasmic C-terminus) of rat Neuroligin-1. Mouse: 99% identity (125/126 amino acids identical). Human: 99% identity (125/126 amino acids identical) >40% identity with Neuroligin-2 and -3.

Target

Neuroligin 1

Clonality

Monoclonal

Isotype

IgG1

Clone

N97A/31 (Formerly sold as S97A-31)

Conjugation

Unconjugated

Validated Applications

WB,IHC,ICC/IF

Purification

Protein G Purified

Limit Of Detection

2 µg/ml of SMC-463 was sufficient for detection of Neuroligin-1 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Weight

0.012

Buffer

PBS pH7.4, 50% glycerol, 0.1% sodium azide

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Product MSDS

https://cdn.gentaur.com/products/400/4292119/msds/smc-463s.pdf

CAS Number

9007-83-4

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